The 10 Best Growth Factor Serums for More Youthful-Looking Skin, According to Dermatologists

If you’re looking for one of the best, and first, growth factor serums, look no further than this option from SkinMedica, says Dr. Lal, who notes that it has been shown in studies to give the skin a more rejuvenated appearance. This serum is also a favorite of Dr. Garshick, as it “uses a blend of a next-generation growth factor as well as an innovative peptide complex to help nourish the skin,” while smoothing the appearance of fine lines and wrinkles and improving skin tone and texture.

This option from The Inkey List is both effective and affordable. Dr. Lal appreciates that it contains oligopeptide-1 which he refers to as “a true growth factor.” This lightweight serum also contains vitamin C, making it a great option for those looking for a brighter complexion in addition to a smoother, more lifted appearance.

Dr. Lal recommends this growth factor serum for its ability to lift and firm the skin using an innovative formula. Not only does this serum contain growth factors, but it also boasts retinol to maximize the skin-boosting benefits. Retinol benefits overlap with growth factor benefits like lifting, firming, and brightening as both ingredients aid in collagen production, but the retinol in this formula also aids with skin renewal and exfoliation.

For those with more sensitive skin, this formula is enriched with centella asiatica, which “helps to firm the skin while also soothing the skin,” explains Dr. Garhsick. “Providing both immediate and long term results, this serum helps to tighten, smooth, and restore.”

Dr. Lal says that this serum from ZO Skin Health is a “very good product,” in that it helps reduce the visible signs of aging like fine lines, loss of elasticity, and uneven tone and texture. And while growth factors in general help to maintain skin hydration, this lightweight gel formula kicks things up a notch with ingredients like glycerin, red ginseng extract, and a proprietary blend that “supports skin’s natural replenishment of hyaluronic acid,” according to the brand.

“This serum works to help to lift and firm the appearance of the skin, while also reducing the appearance of fine lines and wrinkles,” explains Dr. Garshick. “It uses a patent-pending Micro Growth Factor Technology offering deeper penetration to help support collagen production.”

“This topical serum contains both growth factors and proprietary peptides to improve the overall appearance of fine lines and wrinkles while improving skin texture, overall firmness and elasticity, and boosting hydration,” Dr. Garshick says. “It is safe to use on the face, neck, and décolleté one to two times per day and can be followed by a moisturizing cream.”

This lightweight and oil-free serum can be used by all skin types, according to Dr. Garshick. “Containing antioxidants like vitamin C, niacinamide, and hyaluronic acid, this serum helps to brighten and hydrate the skin.” Plus, it helps reduce the signs of sun damage. “It also incorporates a high level of growth factors to help repair the skin and improve signs of skin aging.”

The Youth Eye Complex from iS Clinical pairs perfectly with the iS Clinical Youth Serum recommended by Dr. Garshick. This eye serum uses the same growth factor blend to reduce fine lines and wrinkles around the delicate eye area while also providing hydration and providing antioxidant protection. “This product has really helped with the dark circles under my eyes. After using this cream I can really feel the difference and the skin feels tighter and smoother,” wrote one Dermstore reviewer. “I don’t have many wrinkles on my eyelids after using this cream. Best cream ever.”

Growth factors are paired with powerful peptides in this serum to combat the visible signs of aging such as fine lines and wrinkles, loss of elasticity, and dullness. Plus, you can rest assured knowing it contains oligopeptide-1, which gets Dr. Lal’s stamp of approval in terms of growth factors. “This stuff is fab! It absorbs almost immediately and really does wonders for my fine lines,” wrote one Amazon reviewer. “It really plumps up and is so smooth!”